Brain Health — Episodes

5 curated episodes

67 min · Oct 2025 · #283

Brain health: insulin resistance, biomarkers, and Alzheimer's risk

Dr. David Perlmutter — Perlmutter Health Center; Board-certified neurologist & New York Times bestselling author

Insulin resistance in the brain precedes Alzheimer's symptoms by decades. The biomarkers that reveal risk early — fasting insulin, homocysteine, ApoE — and what interventions work.

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80 min · Aug 2023 · #228

Role of nutrition for brain health

Dr. Georgia Ede; Dr. Dominic D'Agostino, PhD — Harvard-trained psychiatrist & nutrition specialist (Ede); University of South Florida (D'Agostino)

Psychiatric symptoms are often metabolic symptoms. How a ketogenic diet lowers insulin and CRP in ways that affect mood, which conditions respond best, and how to tailor it safely.

65 min · May 2023 · #214

Is fructose a driver of Alzheimer's disease?

Dr. Richard Johnson, MD; Dr. Robert Lustig, MD — University of Colorado School of Medicine (Johnson); UCSF (Lustig)

Fructose activates a foraging survival pathway in the brain — one that may be hijacked in Alzheimer's. The evolutionary mechanism behind fructose-driven cognitive decline.

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103 min · Nov 2022 · #221

Can food and the keto diet affect your mental health?

Dr. Chris Palmer, MD — Harvard Medical School / McLean Hospital; Psychiatrist & researcher; author of Brain Energy

Mental disorders are metabolic disorders of the brain. How a ketogenic diet shifts neurotransmitters, and why schizophrenia, bipolar, and depression have mitochondrial signatures.

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79 min · Jun 2022 · #213

Uric acid: a key cause of weight gain, diabetes, heart disease, and dementia

Dr. David Perlmutter, MD — Perlmutter Health Center; Board-certified neurologist & New York Times bestselling author

Uric acid above 5.5 mg/dL drives fat storage, insulin resistance, and neuroinflammation — even without gout. Which foods raise it, what optimal looks like, and how to lower it.

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