Aging — Episodes

6 curated episodes

94 min · Apr 2026 · #297

Does Most Chronic Disease Come Down to "Energy Flow?" | Greg Mushen and Josh Clemente

Greg Mushen — Technologist & systems thinker; writes Dark Lab; focuses on metabolic health, exercise physiology, and "flux" models

Why "metabolic flux" (clearance capacity) beats static markers—plus the movement threshold, walking/VO₂ max debate, and practical steps to reverse insulin resistance.

71 min · Apr 2026 · #296

The Truth About Protein: Why Exercise is Key to Muscle & Longevity

Dr. Stuart Phillips — McMaster University; Professor of Kinesiology & Director, Physical Activity Centre of Excellence

Protein alone doesn't build muscle — exercise does. Why the RDA is too low, how anabolic resistance accelerates with age, and what optimal intake actually looks like.

Read the companion article →

105 min · Dec 2025 · #287

Male hormones and men's health

Dr. Jesse Mills — UCLA Men's Clinic; Director

Testosterone isn't just about libido. How to tell reversible low-T from real deficiency, why lifestyle changes often work before prescriptions, and what labs can mislead.

Read the companion article →

89 min · Nov 2025 · #285

Immune health: inflammation, white blood cells, and resilience

Dr. Sharon Bergquist — Emory University; Physician & Director, Emory Healthy Aging and Resilience Center

Immune resilience isn't the same as immune strength. Why chronic inflammation is a metabolic problem, how the immune system ages, and what daily habits shift your baseline.

Read the companion article →

67 min · Oct 2025 · #283

Brain health: insulin resistance, biomarkers, and Alzheimer's risk

Dr. David Perlmutter — Perlmutter Health Center; Board-certified neurologist & New York Times bestselling author

Insulin resistance in the brain precedes Alzheimer's symptoms by decades. The biomarkers that reveal risk early — fasting insulin, homocysteine, ApoE — and what interventions work.

Read the companion article →

110 min · Sep 2025 · #282

Longevity biomarkers for healthy aging

Dr. Matt Kaeberlein, PhD — Optispan; CEO & longevity researcher; former Professor, University of Washington

Which biomarkers predict healthy aging vs. just longevity. How mental and physical health connect at the cellular level, and where the science on lifespan interventions stands.

Read the companion article →