A Whole New Level — More topics

13 curated episodes

94 min · Apr 2026 · #297

Does Most Chronic Disease Come Down to "Energy Flow?" | Greg Mushen and Josh Clemente

Greg Mushen — Technologist & systems thinker; writes Dark Lab; focuses on metabolic health, exercise physiology, and "flux" models

Why "metabolic flux" (clearance capacity) beats static markers—plus the movement threshold, walking/VO₂ max debate, and practical steps to reverse insulin resistance.

67 min · Mar 2026 · #295

The Science of Preconception: Measuring Fertility, Toxins, and Generational Health

Dr. Ann Shippy — Board-certified internal medicine physician; functional medicine practitioner; author of The Preconception Revolution

Why fertility problems are often early metabolic warning signs. How toxins, mitochondria, and microbiome interact — and why three months is the minimum window to shift outcomes.

67 min · Oct 2025 · #283

Brain health: insulin resistance, biomarkers, and Alzheimer's risk

Dr. David Perlmutter — Perlmutter Health Center; Board-certified neurologist & New York Times bestselling author

Insulin resistance in the brain precedes Alzheimer's symptoms by decades. The biomarkers that reveal risk early — fasting insulin, homocysteine, ApoE — and what interventions work.

Read the companion article →

110 min · Sep 2025 · #282

Longevity biomarkers for healthy aging

Dr. Matt Kaeberlein, PhD — Optispan; CEO & longevity researcher; former Professor, University of Washington

Which biomarkers predict healthy aging vs. just longevity. How mental and physical health connect at the cellular level, and where the science on lifespan interventions stands.

Read the companion article →

94 min · Jul 2025 · #278

How your gut microbiome affects your health

Dr. Will Bulsiewicz, MD MSCI — ZOE; US Medical Director & board-certified gastroenterologist; author of Fiber Fueled

Gut bacteria produce postbiotics that regulate immunity, metabolism, and mood. Why diversity is the goal, how emulsifiers disrupt the gut barrier, and what to eat to rebuild it.

Read the companion article →

80 min · Aug 2023 · #228

Role of nutrition for brain health

Dr. Georgia Ede; Dr. Dominic D'Agostino, PhD — Harvard-trained psychiatrist & nutrition specialist (Ede); University of South Florida (D'Agostino)

Psychiatric symptoms are often metabolic symptoms. How a ketogenic diet lowers insulin and CRP in ways that affect mood, which conditions respond best, and how to tailor it safely.

60 min · Apr 2023 · #210

Pregnancy and metabolic health: hormone changes and gestational diabetes

Azure Grant, PhD — Metabolic health researcher & circadian biologist

Insulin resistance drives PCOS and infertility. How metabolic health affects each trimester, and which interventions reduce gestational diabetes risk.

Read the companion article →

49 min · Feb 2023 · #201

Exploring the intersection of healthcare and artificial intelligence

Peter Diamandis, MD — XPRIZE Foundation & Singularity University; Founder & Executive Chairman

AI won't just find information — it will personalize health interventions in real time. Why the next decade of medical breakthroughs will exceed the last hundred years combined.

Read the companion article →

53 min · Jan 2023 · #198

How functional medicine focuses on personalized health

Dr. Anjali D'Souza, MD — District Center for Integrative Medicine; Integrative & functional medicine physician

A 12-minute appointment can't find root causes. How functional medicine uses biomarkers to trace symptoms to mechanisms — and why this matters especially for women.

Read the companion article →

103 min · Nov 2022 · #221

Can food and the keto diet affect your mental health?

Dr. Chris Palmer, MD — Harvard Medical School / McLean Hospital; Psychiatrist & researcher; author of Brain Energy

Mental disorders are metabolic disorders of the brain. How a ketogenic diet shifts neurotransmitters, and why schizophrenia, bipolar, and depression have mitochondrial signatures.

Read the companion article →

79 min · Jun 2022 · #213

Uric acid: a key cause of weight gain, diabetes, heart disease, and dementia

Dr. David Perlmutter, MD — Perlmutter Health Center; Board-certified neurologist & New York Times bestselling author

Uric acid above 5.5 mg/dL drives fat storage, insulin resistance, and neuroinflammation — even without gout. Which foods raise it, what optimal looks like, and how to lower it.

Read the companion article →

57 min · Jun 2022 · #127

Unveiling metabolic health disparities in diverse communities

Dhru Purohit; Austin McGuffie — Dhru Purohit: Entrepreneur & health investor; Austin McGuffie: Content creator & Metabolism Mentor

Metabolic disease rates differ sharply across South Asian and Black communities due to food culture, not just genetics. Why community-specific approaches change outcomes.

Read the companion article →

29 min · Mar 2022 · #87

Inflammation and metabolic health

Dr. Taylor Sittler, MD — Levels; Head of Research & Development

Acute inflammation heals; chronic inflammation destroys. How blood glucose drives the inflammatory cascade, why CRP rises with metabolic dysfunction, and what lowers both.

Looking for another old episode? Browse the full archive on YouTube or Apple Podcasts.